BDBM330291 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-5-yl)-3-(4-((2-((4-hydroxyphenyl) amino)pyrimidin-4-yl)oxy)naphthalen-1- yl)urea::US10238658, Example 33::US10813932, Example 33::US9724347, Example 33::US9993478, Example 33

SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(O)cc3)n2)c2ccccc12)C(C)(C)C

InChI Key InChIKey=YEMXWTXOSTZPEB-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 330291   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM330291(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Affinity DataIC50:  60nMAssay Description:p38 MAPKα: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330291(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Affinity DataIC50:  60nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330291(1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H- pyrazol-...)
Affinity DataIC50:  60nMAssay Description:p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent